Cisplatin cold sensitivity
WebFor example, drugs like cisplatin, docetaxel, and paclitaxel can damage nerves. This can sometimes lead to symptoms (mainly in the hands and feet) such as pain, burning or tingling, sensitivity to cold or heat, or weakness. This is called peripheral neuropathy. WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been noted …
Cisplatin cold sensitivity
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WebJan 24, 2024 · oversensitivity to touch balance and coordination problems, which can lead to stumbling or falling when walking differences in your sensitivity to temperature, making it harder to gauge heat and... WebJan 12, 2024 · Cervical cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely utilized in locally advanced cervical cancer patients. However, resistance has been the major limitation. In this study, we found that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) was downregulated in cisplatin …
WebApr 1, 2024 · NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma cells. However, NKX2-1 as a dual role in tumor progression depended on p53 mutational status via modulation of the NF-κB pathway. WebMay 26, 2024 · Cisplatin is a widely used drug in the treatment of various solid tumors, such as ovarian cancer. However, while the acquired resistance significantly limits the success of therapy, some tumors, such as colorectal cancer, are intrinsically insensitive to cisplatin. Only a small amount of intracellular platinum binds to the target-genomic DNA.
WebMay 1, 2003 · Taniguchi et al. propose that targeted inhibition of FANC proteins might increase the sensitivity of cancer cells to cisplatin. This is quite a leap—much more … WebAug 24, 2024 · Cisplatin (CDDP) remains one of the most widely used first-line drugs in the therapy of NSCLC, based on the clinical data that the poor outcomes of untreated …
WebFeb 24, 2024 · One of the most common long-term side effects of Platinol (cisplatin), a medication used for many cancers including lung cancer, is ototoxicity (damage to the structures of the ear). Other medications may also cause hearing loss and tinnitus (ringing in the ears). Skeletal Effects
WebNational Center for Biotechnology Information how do you play eight ball on imessageWebJul 28, 2012 · Background: Oxaliplatin, a platinum-based chemotherapeutic agent, causes an unusual acute peripheral neuropathy. Oxaliplatin-induced acute peripheral … how do you play double six dominoesWebJul 14, 2024 · Oxaliplatin-induced acute neuropathy is characterized by cold sensitivity, throat discomfort, discomfort swallowing cold liquids, and muscle cramps. Although some of these symptoms can occur within the time of drug infusion, their severity usually peaks 2 to 3 days after each dose of oxaliplatin. phone is offline find my iphoneWebBased on the IC 50 values obtained, the resistance to cisplatin varies following the rank order: A549 > NCI-H228 > Calu-3 > NCI-H1975 cells. The cytotoxicity of cisplatin, … how do you play eraser dropWebFeb 16, 2024 · Cisplatin side effects. Get emergency medical help if you have signs of an allergic reaction: hives; fast heartbeats, feeling light-headed; wheezing, difficulty … how do you play draft kingsWebJun 29, 2024 · A possible sensitivity to cisplatin could be restored in Cal 27 cells by CAP application. CAP shows strong cytostatic effects in HNSCC cell lines that can be … phone is on but black screenWebSep 15, 2024 · Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL multiple dose … how do you play egyptian bowling