Proton-coupled folate transporter
WebbEnergy coupling factor (ECF) transporters are responsible for the uptake of micronutrients in bacteria and archaea. They consist of an integral membrane unit, the S-component, and a tripartite ECF module. It has been proposed that the S-component mediates the substrate transport by toppling over in the membrane when docking onto an ECF module. WebbGastric acid releases the vitamin from food particles; therefore antacid and acid-blocking medications (especially proton-pump inhibitors) may inhibit absorption of B 12. After B 12 has been freed from proteins in food by pepsin in the stomach, R- protein (also known as haptocorrin and transcobalamin-1), a B 12 binding protein that is produced in the salivary …
Proton-coupled folate transporter
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Webb20 maj 2024 · SLC46A3 is an orphan transporter that belongs to the SLC46A family, which includes a well-characterized protein, proton-coupled folate transporter (PCFT also known as SLC46A1) (11, 15). Given its significant similarity with PCFT based on amino acid sequence and membrane topology, SLC46A3 likely functions as a membrane transporter … Webb19 maj 2011 · Qiu et al. (2006) identified PCFT as a proton-coupled high-affinity folate transporter that operates at low pH in the intestine. Nakai et al. (2007) showed that PCFT expressed transiently in human embryonic kidney cells mediated transport of folate at an extracellular pH of 5.5 in a manner independent of Na+ and insensitive to membrane …
WebbTumor Targeting with Novel Pyridyl 6 ‑ Substituted Pyrrolo[2,3 ‑ d ]Pyrimidine Antifolates via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis Journal of Medicinal Chemistry February 9, 2024 Webb21 mars 2024 · This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system.
Webb26 maj 2024 · The proton-coupled folate transporter (PCFT) (also known as SLC46A1) mediates folate uptake across the intestinal brush border membrane and the choroid … WebbI have a PhD in biochemistry and am working as a senior research engineer at Umeå University, Sweden. My research is focussed on a transport system (Type 4 secretion systems) that bacteria use to spread antibiotic resistance and virulence factors. You can find more details about me & my work on my website: josyterbeek.wordpress.com …
Webb29 mars 2024 · proton-coupled folate transporter, heme carrier protein 1, solute carrier family 46 (folate transporter), member 1. GeneRIFs: Gene References Into Functions. …
WebbFRα is a membranous glycoprotein and facilitates folate uptake via endocytosis of the folate-bound receptor. 5–7 While expression in normal tissue is rare, FRα is commonly found in cancers, such as lung adenocarcinoma, breast and ovarian cancer. 8–12 The prognostic role of FRα in cancer is controversial since it is linked to a better and worse … great wall north point roadWebbIdentification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell. 2006 Dec 1;127(5):917-28. doi: 10.1016/j.cell.2006.09.041. Citation on PubMed; Wolf G. Identification of proton-coupled high-affinity human intestinal folate transporter mutated in human hereditary familial folate malabsorption. florida health inspections restaurantsWebbReconstruction of Coupling in the Brain at Epilepsy from Local Field Potentials Using Model Neurooscillators . × Close Log In. Log in with Facebook Log in with Google. or. Email. Password. Remember me on this computer. or reset password. Enter the email address you signed up with ... great wall nouméaWebb3 mars 2010 · The proton-coupled folate transporter (PCFT) mediates intestinal folate absorption. Loss-of-function mutations in this gene are the molecular basis for the … florida health insurance subsidyWebb1 aug. 2024 · The genes affected include duodenal folate receptor (Folr) and dihydrofolate reductase (Dhfr), jejunal proton-coupled folate transporter (Pcft) and reduced folate carrier (Rfc), and ileal ATP ... florida health insurance freeThe proton-coupled folate transporter is a protein that in humans is encoded by the SLC46A1 gene. The major physiological roles of PCFTs are in mediating the intestinal absorption of folate (Vitamin B9), and its delivery to the central nervous system. Visa mer PCFT is located on chromosome 17q11.2 and consists of five exons encoding a protein with 459 amino acids and a MW of ~50kDa. PCFT is highly conserved, sharing 87% identity to the mouse and rat PCFT and retaining more … Visa mer PCFT-mediated transport into cells is optimal at pH 5.5. The low-pH activity and the structural specificity of PCFT (high affinity for folic acid, and low affinity for PT523 - a non … Visa mer The physiological role of PCFT is known based upon the phenotype of subjects with loss-of-function mutations of this gene – the rare … Visa mer PCFT is expressed in the proximal jejunum with a lower level of expression elsewhere in the intestine. Expression is localized to the apical membrane … Visa mer Because of the Warburg effect, and a compromised blood supply, human epithelial cancers grow within an acidic milieu, as lactate is produced during anaerobic glycolysis. … Visa mer florida health insurance for kidWebb6 sep. 2012 · On the other hand, the proton-coupled folate transporter (PCFT), the second route by which folates are taken up by the cell, is also considered a target for antifolate … florida health insurance quotes online